Phoenix winnonlin manual2/12/2023 It can be seen this small bias is caused by the difference of WNL's Tinv(0.1,22) and my Manual Tinv(0.1,22). Precision is only at the lelvel of 0.01(%), Incrediable? Interesting? Strange?Ĭan anyone give me the result of PNX WNL 6.0 or later version? Dear HS or ElMaestro or others warm-hearted? Manual 90% CI of GeoMean Ratio(%) (T/R) based on WNL‘s 90% CI of LSMean(R-T) Here I find the above 90% CI of GMR is lack of precision.Īccording to Phoenix WinNonlin 6.0 guide : Select Ln()-transformation in WNL's BE wizard.įor comparison, I list some critical results: My dataset is Chow and Liu's famous data:ĭesign and Analysis of Bioavailability and Bioequivalence Studies, Third Edition. When I am validating WNL's BE (v 5.1.1) results by comparing the results of WNL with those of my manual calculation, I find that WNL's BE's 90% CI of the Ratio is lack of precision.
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